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UBM devices are manufactured by harvesting and minimally processing porcine bladders.
This preserves the integrity of essential structures and molecular components so that only two distinct layers remain:.png?width=1050&height=549&name=UBM%20provides%20an%20environment%20where%20the%20body%20is%20more%20likely%20to%20exhibit%20a%20higher%20ratio%20of%20M2%20to%20M1%20macrophages%2c3%2c7%20which%20has%20been%20shown%20to%20facilitate%20the%20remodeling%20of%20site-appropriate%20tissue.3%20(3).png)
Characteristics of UBM
UBM devices are biologically-derived, three-dimensional scaffolds, which contain a collection of collagens and other proteins including laminin, proteoglycans,1 and numerous growth factors.2
The resulting product is:
- Non-crosslinked
- Resorbable
- Decellularized
Cellular Responses to UBM
After a UBM device is placed in the body, white blood cells including macrophages and neutrophils will enter the UBM scaffold to initiate the remodeling response. Fibroblasts will also enter the scaffold, depositing various collagens that provide strength and structure for the new tissue, and new blood vessels will form transporting blood and nutrients to the site of repair.3-6
UBM provides an environment where the body is more likely to exhibit a higher ratio of M2 to M1 macrophages,3,7 which has been shown to facilitate the remodeling of site-appropriate tissue.3
UBM supports the development of healthy tissue that mimics the structure and biomechanical functionality of the surrounding anatomy. Over time, the devices will fully resorb and completely remodel into the host tissue, leaving no foreign body.3-6